A man and woman have been charged after they allegedly shot at a man before assaulting and robbing him in Melbourne's south.

Police allege a man was walking along Scott Street in Dandenong when a shot was fired from a car about 5.30am yesterday.

The pair got out of the car after the shot was allegedly fired and assaulted man.

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"A number of personal belongings were then stolen from the 32-year-old man," Victoria Police said in a statement.

"He was taken to hospital where he remains with serious injuries."

A 30-year-old Burwood man was charged with armed robbery, prohibited person possess firearm, prohibited person use firearm, intentionally cause serious injury and recklessly cause serious injury.

A 29-year-old Burwood woman has been charged with armed robbery, intentionally cause serious injury and recklessly cause serious injury.

They are due to face Melbourne Magistrates' Court today.