Several suspects are still on the run after pelting rocks at a bus on the Gold Coast, causing it to crash into a tree.

The passenger bus, which had a driver and five people on board, was the target of several people on e-bikes who threw rocks at it just before 11.30pm last night on Teemangum Street in Currumbin.

This caused the driver to lose control, and the bus left the road and collided head on with a tree.

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None of the passengers were injured, but the female bus driver was taken to hospital as a precaution.

Police are investigating the incident and are still searching for the people involved.

The company that runs the bus said it was appalled by the act of violence, and that drivers did not deserve the kind of abuse they faced.

"This was a deeply distressing incident for the bus driver and passengers involved, and we are in contact with those affected to offer our support," Kinetic executive general manager for south-east Queensland Tom Kinsey said in a statement.

"Attacks on our drivers and passengers are completely unacceptable. We strongly condemn any behaviour that puts the safety of our drivers, the passengers on board and the community at risk."

Anyone who witnessed the crash, or has any CCTV or dashcam footage is urged to come forward.

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