A murder investigation is underway after a man was found dead inside a home in Brisbane's Cannon Hill.

Police conducting a welfare check in the quiet cul-de-sac found the body of the 59-year-old inside the home just before 3pm.

Paramedics were called but the man could not be revived.

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The man is understood to have driven to the home in a white ute before a violent altercation broke out.

9News understands a knife was seized at the scene.

A neighbour said she was home throughout the afternoon but was not aware there had been a disturbance until police arrived.

A 29-year-old man who is known to the victim is assisting police.

Charges are yet to be laid.