Over 1000 people have marched down Bourke Street towards Melbourne's Parliament House to protest against the state's vaccine mandates and a proposed COVID-19 pandemic bill.
At times, protesters shouted "free Victoria" and "sack Dan Andrews" as they marched.
Many are displaying anger over the proposed bill that would allow COVID-19 rules to remain during global pandemics, rather than relying on state emergency powers.
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People first started gathering in front of the State Library in Melbourne's CBD.
Many carried signs with anti-vaccination sentiments and some against the government reading "dangerous new legislation".
Melbourne police are at the scene.
A Victoria police spokesperson told 9News police are aware of the activity in Melbourne and that a high visible police presence will be there to ensure no COVID-19 breaches occur.