One Nation leader Pauline Hanson says Australia is in "a real mess" and traced the surge in support for her party to the two majors failing to deliver outcomes for the community.

Her comments come after One Nation won a seat in the House of Representatives for the first time, with David Farley claiming former Liberal leader Sussan Ley's spot in a thumping victory that has sent shockwaves through Australian politics.

Farley secured 57 per cent of the two-party preferred vote, leaving the Liberal Party to poll at just 12 per cent, raising questions about its future.

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Hanson said the result "vindicated" her party and proved it was not a flash in the pan but providing hope for Australians.

"I stuck to my guns, what I believed in," she told 2GB radio in Sydney.

"I felt that the country was in one hell of a mess and the major political parties were not addressing the needs and concerns of the Australian people.

"I just feel that there was no future for our generations to come. And a lot of the young ones were coming up to me and people, whether they were small business, industries, manufacturing, the farming sector, just ordinary Australians saying they had no hope for the future."

She took aim at Liberal leader Angus Taylor, who claimed a rising One Nation vote would only keep Labor in power.

"They are so arrogant, and Angus Taylor is so arrogant with their attitude like it's just a two-party system in Australia," she said.

"He's trying to justify the whole thing… why you should only stick with the two major political parties. He's not going back… he needs to have a good look in the mirror why it's happening this way, because they have not delivered for the Australian people."

She refused to confirm whether she would look to use the uptick in One Nation support to gun for a House of Representatives spot of her own at the 2028 election (Hanson is a senator in the Upper House), but she admitted with the changing fortunes of the party, anything could happen for her and MP Barnaby Joyce.

"When Barnaby came across, he indicated he did want to stand for the Senate. But the way that it's going at the moment, as I said to Barnaby, 'Your position might be better in the lower house.' And that's something that I'm also considering myself," she said.

Joyce reveals next One Nation target

Joyce said the Farrer victory had emboldended One Nation to target urban seats in parts of Sydney with the aim of forming government.

"I tell you what, I've met some people from the western suburbs of Sydney who are pretty happy that One Nation is on the move," he said on Today.

"This is not an issue that is about regional Australia, this is about [all of] Australia."

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He said recent results in Farrer and in the South Australian state election had removed previous tags over the party, and that One Nation was aiming to be in power rather than "maintaining the status quo".

"I don't think people see One Nation as racist; they view them as tough," he said.

"People say Labor are so strong in the western suburbs, Labor didn't even turn up to the Farrer by-election, that's how strong they are."

He also dismissed the idea that the route back to power for the conservative side of politics was to win back inner-city seats.

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"[People say] 'You've got to win back teal seats'; no you don't, you've got to look after people in the regional areas and the western suburbs of the major capitals," he claimed.

Some commentators have suggested the Liberal Party and One Nation could come together to form a Coalition government that could challenge Labor, an idea that was not dismissed by Liberal MP Tim Wilson yesterday.

However, Joyce insisted this was off the table, saying he would rather chase "policy outcomes" than ministries.

"We don't want your ministries, keep your ministries and your salaries. You've got all of the prizes, but you will deliver policy outcomes, because we will not be constricted by cabinet solidarity that has done over the Australian people," he said.

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