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Two adults and two teenage boys have been found dead in a suspected murder-suicide at a home in Perth's west.

Police were called to the house at Mosman Park about 8.15am (AWST) after a person known to the family became concerned for their welfare.

Inside officers discovered the bodies of four people, including a 50-year-old male, a 49-year-old female and two boys aged 14 and 16. Two dogs and a cat were also found deceased.

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Police said the four were part of a family unit, and they were aware that the children had experienced "significant health challenges".

"Although this investigation is in its infancy, police are investigating this matter as a murder-suicide," WA Police detective acting inspector Jessica Securo said.

"This tragic incident occurred only this morning and it will take time for police to investigate the circumstances.

Securo said no weapon was during the incident and the family had no reported family violence matters and were not known to police at all.

She said a note was left at the premises.

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"We do know that both children experienced significant health challenges," she said.

"This is a highly distressing situation for all involved, from community members to the person who located the family to our first responders.

"WA police force has engaged our health and welfare and support services for all our front-line staff who attended this incident.

"If this incident has adversely affected or impacted you, I urge you to speak to your loved ones and get some help and assistance."

Readers seeking support can contact Lifeline on 13 11 14, or beyond blue on 1300 22 4636.

National Sexual Assault, Domestic Family Violence Counselling Service 1800RESPECT (1800 737 732).

Victims include tourists, school friends, a tutor and a 10-year-old boy.