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Two adults and two teenage boys have been found dead in a suspected murder-suicide at a home in Perth's west.

Police were called to the house at Mosman Park about 8.15am (AWST) after a person known to the family became concerned for their welfare.

Inside officers discovered the bodies of four people, including a 50-year-old male, a 49-year-old female and two boys aged 14 and 16. Two dogs and a cat were also found deceased.

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Police said the four were part of a family unit, and they were aware that the children had experienced "significant health challenges".

"Although this investigation is in its infancy, police are investigating this matter as a murder-suicide," WA Police detective acting inspector Jessica Securo said.

"This tragic incident occurred only this morning and it will take time for police to investigate the circumstances.

Securo said no weapon was during the incident and the family had no reported family violence matters and were not known to police at all.

She said a note was left at the premises.

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"We do know that both children experienced significant health challenges," she said.

"This is a highly distressing situation for all involved, from community members to the person who located the family to our first responders.

"WA police force has engaged our health and welfare and support services for all our front-line staff who attended this incident.

"If this incident has adversely affected or impacted you, I urge you to speak to your loved ones and get some help and assistance."

Readers seeking support can contact Lifeline on 13 11 14, or beyond blue on 1300 22 4636.

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Seven men are facing serious drug and firearm charges following their alleged involvement in a criminal syndicate supplying drugs throughout Sydney.

Following extensive investigations into the syndicate, detectives executed a search warrant at a Granville home on January 20, earlier this month.

An additional eight homes in Hurstville, Riverwood, Revesby, and Beverly Hills were searched yesterday.

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During the searches, police found and seized over 28kg of prohibited drugs, three firearms, more than $1 million in cash and a large quantity of steroids.

A ballistic vest and more than 800 rounds of ammunition were also located and seized.

The combined street value of the drugs seized totalled $3 million, including 24.9kg of methylamphetamines and 2.9kg of heroin confiscated by police.

At Granville, a 26-year-old man was arrested and taken to Granville Police Station, where he was charged with fifteen offences, including supplying prohibited drugs in a large commercial quantity and three counts of possession of an authorised pistol.

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He was refused bail and was remanded to appear before Parramatta Court on March 23.

During yesterday's searches, five men, aged 30, 31, 32, 33 and 65, were arrested and taken to Hurstville Police Station, where they were charged with multiple offences.

The men were charged with large commercial drug supply, dealing with proceeds of crime and participating in a criminal group.

They were all refused bail and will face Sutherland Court today.

A sixth man, aged 68, was charged with supplying an indictable quantity of drugs and dealing with proceeds of crime.

He was granted conditional bail to appear before the Sutherland Court on March 17.

Investigations are still ongoing.

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