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A man is on the run after another man was shot dead and two others were injured in NSW's north-east.

A police operation commenced after reports of a shooting on Tyalgum Road at Eungella, south-west of Tweed Heads, about 1.25pm.

Officers were told two men – aged 41 and 38 – were shot by another, who fled the scene with a fourth man.

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Paramedics treated the 41-year-old man for a gunshot wound, however, he died at the scene.

He is yet to be formally identified.

Shortly after, police were informed of a second incident on the same road after a 45-year-old man was allegedly hit by a car.

He is being treated at Gold Coast University Hospital and remains under police supervision.

The 38-year-old man subsequently sought treatment at hospital for a gunshot wound.

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Police are now waiting to speak with the 38-year-old and 45-year-old to establish the circumstances surrounding their injuries.

Police are working to locate the fourth person, believed to be aged 37.

Authorities believe the man is unarmed.

The road has been closed, and police remain on-site searching the area with police dogs.

Anyone with information should call Crime Stoppers on 1800 333 000 or make an online report.

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The North Island is cloaked in warnings and watches today.

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Another teacher was caught sniffing white powder from a classroom desk.

New details have emerged about a teacher who is accused of stabbing a principal at a secondary school in Melbourne.

Police swarmed Keysborough Secondary College in the city's south-east about 3pm yesterday after principal Aaron Sykes, 43, was allegedly slashed in the arm and lip with a kitchen knife by Kim Ramchen.

The court heard today that the IT teacher, 37, allegedly snapped after learning his contract would not be renewed.

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Sykes was taken to hospital with non-life-threatening injuries and has since been released.

Ramchen was pulled away from staff who heard the commotion, the court heard.

Staff managed to pin him down after he allegedly returned to the office with a second knife.

The school went into lockdown following the incident.

"Me and my friends, we quickly ran into the food tech room and then we just hid there," one student told 9News.

Ramchen was arrested at the scene and was taken to hospital with a minor injury, where he remained under police guard.

He has since been charged with two counts of unlawful assault, one count of intentionally causing injury, recklessly engaging in conduct placing a person in danger of serious injury and assault with a weapon.

He appeared before Dandenong Magistrates' Court today.

Ramchen's brother told the court his brother is a quiet person and that he was shocked to hear about the alleged stabbing.

Ramchen was refused bail and will return to court on January 6.

In a letter sent to parents, the school said Sykes was "recovering well and is in good spirits".

The school also assured parents that no student was involved in the incident.

"Any form of violence within our school is entirely unacceptable. We are proud of the safe and supportive culture that is the norm at our school," the note read.

"We want to assure you that the health and safety of our students and staff is always our highest priority."

The school has reopened today.

An investigation into the incident remains ongoing. 

Anyone who witnessed the incident, has footage or any information that could assist police is urged to contact Crime Stoppers.

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The total compares with more than 12,000 financial sanctions in half that time.