Tag Archives: oceania

Beta blockers could halt triple-negative breast cancer, new study suggests

Australian researchers have uncovered a potential way to stop the spread of triple-negative breast cancer (TNBC), an aggressive and often difficult-to-treat form of the disease. 

A new study by Monash University researchers has identified a key genetic switch that could determine which triple-negative breast cancer patients could benefit from beta blocker therapy.

The findings, published in the journal Science Signaling, identify a specific gene that acts as a "switch" for tumour progression, and could help doctors determine which patients would benefit from beta blocker medication.

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A woman receives radiation therapy treatment for breast cancer.

Beta blockers are a class of drugs commonly used to treat high blood pressure and other heart conditions.

They work by blocking the blocking stress hormones.

However, Monash researchers have been investigating their potential to fight cancer.

Previous studies by the university have shown a link between beta blocker use and improved outcomes for some TNBC patients, but the reason for this was unclear – until now.

The science behind the switch

The Monash Institute of Pharmaceutical Sciences team focused on the body's natural stress response.

When stress hormones are released, they can activate a receptor called the "beta-2 adrenoceptor," which can accelerate the spread of cancer cells.

The researchers discovered that a complex interplay between two cellular signals, cAMP and calcium, is triggered by the beta-2 adrenoceptor, fuelling cancer progression.

At the centre of this process is a single gene, HOXC12, which acts as the master regulator.

Using the gene-editing tool CRISPR-Cas9, the scientists were able to "delete" the HOXC12 gene, which effectively "switched off" the cancer-promoting cellular signals.

This suggests that the presence of the HOXC12 gene could be the key to identifying patients who would respond well to beta blocker therapy, which works by blocking the effects of stress hormones.

New hope for patients

Associate Professor Michelle Halls, a senior author of the study from MIPS, said the discovery was exciting.

"Our colleagues at MIPS, who were also pivotal to this latest study, have previously found that beta blockers are associated with a significant reduction in mortality in people with TNBC," she said.

"Now we have a much better grasp on why this could be the case. In the Science Signaling study we looked at several TNBC cancer cell types and found that one gene in particular, HOXC12, is a key mediator of the β2-adrenoceptor-cAMP-calcium 'feedforward loop' in TNBC. 

"This information means that if HOXC12 is found to be present in a TNBC patient, they could be an ideal candidate for beta blocker therapy."

Plane forced to land in Italy after flames erupt mid-air

A passenger plane has been forced to make an emergency landing in Italy after flames erupted mid-flight.

Condor Airlines said a "reaction" near the engine had caused flames to appear, but stopped short of describing it as an engine fire.

The plane landed in Brindisi after taking off from Corfu on Saturday night, local time.

READ MORE: Trump rules out sending US troops to Ukraine as part of peace deal

None of the 273 passengers and eight crew on board were injured.

CBS News reported the plane was headed from Greece to Germany before the emergency landing.

Video on social media showed flames flashing on the plane's wing.

Passengers waited overnight for a replacement aircraft which carried them to Dusseldorf in Germany the next day.

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‘Beautiful soul’ remembered as boyfriend fronts court on murder charge

The heartbroken family of a young woman who was killed in the NSW Hunter Valley have paid tribute to the 20-year-old's "beautiful spirit".

Summer Fleming's 31-year-old boyfriend Jethro Gamueda appeared in Parramatta's Bail Court today, charged with her murder.

Fleming was found dead at Gamueda's Rutherford home yesterday after suffering facial injuries.

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The heartbroken family of a young woman who was killed in the NSW Hunter Valley have paid tribute to the 20-year-old's "beautiful spirit".

Gamueda was arrested and charged with her murder.

The couple had been together for just more than a year, having met while working together at Rydges in the Hunter Valley.

Fleming's sister Ash Heggie-Martin told 9News "she was just a beautiful spirit".

"She's just one of a kind," Heggie-Martin said.

Fleming was found dead at Gamueda's Rutherford home yesterday after suffering facial injuries.

"No person deserves to die like that, especially such a beautiful young soul."

Summer, who dreamed of becoming a nurse, is now one of dozens of women allegedly killed at the hands of their partner already this year.

Her name was today added to the She Matters Mural in Melbourne.

Gamueda made no application for bail in court and will remain in custody until his next court appearance in October.

National Sexual Assault, Domestic Family Violence Counselling Service 1800RESPECT (1800 737 732).

Trump and Zelensky’s meeting was a success. So what happens now?

Donald Trump and Volodymyr Zelensky's White House meeting finished without the Ukrainian president being ambushed in the Oval Office, and with both men – as well as the European leaders who also made the trip to Washington – saying the talks were a success.

But it was also the second summit Trump has held in a matter of days, following his meeting with Vladimir Putin in Alaska, that finished without a concrete outcome.

So what happens next? This is what we know.

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President Donald Trump meets with Ukraine's President Volodymyr Zelenskyy in the Oval Office of the White House, Monday, Aug. 18, 2025, in Washington.

What happens now after Trump and Zelensky's meeting?

It appears two more meetings are already on the cards, each involving both Putin and Zelensky.

During the White House meeting, Trump called Putin to organise a sit-down between the Russian president and his Ukrainian counterpart, which would then be followed by a trilateral summit involving all three leaders.

NATO Secretary-General Mark Rutte told Fox News that Putin had agreed to that first meeting.

"He was able, in a conversation with President Putin, to have Putin to agree to first a meeting between Putin and Zelensky," Rutte, who was one of the European Leaders at the White House summit, said.

No dates or locations for either meeting have been set, and the Kremlin hasn't confirmed Putin will attend yet – although foreign affairs advisor Yuri Ushakov said the Russian dictator "spoke favourably" about continuing talks, according to state news agency Tass. 

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Ukrainian President Volodymyr Zelenskyy, from right, President Donald Trump, France's President Emmanuel Macron and Italy's Prime Minister Giorgia Meloni walk through the Cross Hall of the White House, Monday, Aug. 18, 2025, in Washington.

Could that lead to a peace deal between Russia and Ukraine?

No one really knows.

Trump described the White House meeting as "a very good, early step for a War that has been going on for almost four years", and said that "everyone is very happy about the possibility of peace for Russia/Ukraine".

The US president also claimed the fighting could wind down quickly, saying, "a week or two weeks, we'll know whether we're going to solve this".

However, while Zelensky has backed down from demanding a ceasefire before any meeting with Putin, there are still a number of sticking points between the two sides that could get in the way of any peace deal.

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What are the disagreements standing in the way of a peace deal?

It's not a short list, but territory and security are two of the main ones.

Russia currently holds about 20 per cent of Ukrainian territory: the coveted Crimean peninsula it illegally annexed in 2014, as well as large swathes of the Luhansk, Donetsk (which collectively form the Donbas, a crucial industrial hub), Zaporizhzhia and Kherson regions.

It also claims further territory in those four regions that it hasn't fully occupied during the war.

Ukraine, meanwhile, is refusing to cede land to Moscow.

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Ukraine's President Volodymyr Zelenskyy speaks in Lafayette Park, across from the White House, after meeting with President Donald Trump and European leaders Monday, Aug. 18, 2025, in Washington.

"Partners know our red lines – that we do not recognise the occupied territories… this is a violation of international law and the Constitution of Ukraine," Zelensky said recently. 

But at the same time, Ukraine is losing ground in the war – albeit gradually – and doesn't have the military means to retake the land it has lost since 2014. 

Its European allies have talked about the current frontlines being the starting point for negotiations, and Trump has spoken of "land swaps" as a peace condition.

It appears the greater focus for Kyiv is now gaining security guarantees to ensure Russia cannot use the ground it has gained since 2022 to launch another invasion – just as it did with Crimea.

The gold standard of assurances would be NATO membership, thanks to its Article 5, which treats an attack on any one of the allies as an attack on all, but that is out of the question.

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Instead, European leaders have suggested an Article 5-like guarantee for Ukraine without bestowing it official membership, and a peacekeeping force – which Australian troops could join, given Prime Minister Anthony Albanese's openness – on the ground.

Trump signalled his support for those guarantees, saying European countries "want to give protection and they feel very strongly about it and we'll help them out with that", although the exact details remain unclear.

Moscow is vociferously opposed to NATO membership for Ukraine, and while White House envoy Steve Witkoff said Putin agreed to security guarantees during his meeting with Trump over the weekend, more recent statements from the Kremlin suggest otherwise.

Russia "categorically rejects… any scenario that envisages the appearance in Ukraine of a military contingent with the participation of NATO countries", foreign affairs spokesperson Maria Zakharova said yesterday.

Putin has also talked of imposing size limits on Ukraine's army – something Kyiv rejects – while Ukraine has sought the return of children who have been illegally deported to Russia since 2022.

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Ukraine's President Volodymyr Zelenskyy, from left, Finland's President Alexander Stubb and President Donald Trump walk through the Cross Hall of the White House, Monday, Aug. 18, 2025, in Washington.

What about a ceasefire?

Another disagreement has centred around a ceasefire before a permanent peace deal.

Ukraine and its European allies have pushed for one – German Chancellor Friedrich Merz told Trump there should be one in place before another meeting is held.

However, while Trump had previously pressured both Putin and Zelensky to accept a ceasefire, and had threatened more sanctions on Russia if the Kremlin didn't agree to one, that now appears off the table.

The US president changed his position following the meeting with Putin, and has since aligned with the dictator's position that negotiations should focus on a long-term peace settlement instead.

– with Associated Press

Man arrested after woman believed to be his ex-partner found dead

A man has been arrested after a woman believed to be his ex-partner was found dead at a home near the NSW-Victoria border.

Police were called to a home in Cobram about 5am today following reports a 32-year-old woman had been found deceased.

A 45-year-old man has been arrested.

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Cobram homicide probe after woman found dead

"He is known to police and there is a link between that male and our deceased female," Victoria Police Detective Inspector Dean Thomas said today.

It is understood an altercation broke out between the victim and the 45-year-old man.

Two young children who were at the home were not physically injured during the incident.

"Their wellbeing is number one, and making sure they're OK and they're being looked after and provided support that they need," Thomas added.

Cobram homicide probe after woman found dead

9News understands the man did not reside at the addres.

The tight-knit border community has been rocked by the incident.

Neighbours remembered the mother-of-two as a private person who was occasionally seen with her children.

"She was a really quiet lady across the road. She kept to herself. The kids came out the front. Why… why has it happened? We don't know," a neighbour said.

Homicide detectives have driven up from Melbourne today and a forensics team is at the scene.

No charges have been laid.

Cobram is located on the Murray River, on the border between NSW and Victoria, and is about 260km north of Melbourne.

National Sexual Assault, Domestic Family Violence Counselling Service 1800RESPECT (1800 737 732).