Byron Bay and surrounding LGAs will enter a seven-day lockdown from 6pm tonight amid fears COVID-19 may be circulating in the regional areas.

The stay-at-home orders come after a man in his 50s – who travelled from locked down Sydney to Byron Bay – tested positive to COVID-19.

The NSW Government this afternoon confirmed the LGAs of Byron Shire, Richmond Valley, Lismore and Ballina will enter lockdown until 12.01am Tuesday, August 17.

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The restrictions for the areas will be the same as those already in place across Greater Sydney, as well as Tamworth, Armidale, Newcastle, Lake Macquarie. Maitland, Port Stephens, Singleton, Dungog, Muswellbrook and Cessnock.

"Everyone in these areas must stay at home unless they have a reasonable excuse to leave," the NSW Government statement read.

NSW Chief Health Officer Dr Kerry Chant today said officials did not have any information from the infected man's QR check-ins, which are compulsory when visiting venues.

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Dr Chant said the Byron case is understood to have travelled from Sydney at the end of July, at a time when five million people in Greater Sydney were in lockdown.

"Unfortunately this gentleman was infectious in the community for a while, he had symptoms for several days," she said.

"The gentleman himself is actually admitted to hospital at the moment."

The man and his family are being interviewed to ascertain where he travelled and visited, Dr Chant said.

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Earlier today, when asked about the potential development in Byron Bay, Queensland Premier Annastacia Palaszczuk said: "We're starting to hear some issues around that."

She said her team was waiting to "get more information" from their NSW counterparts.

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During the Queensland media briefing it was suggested a traveller from Queensland may have spent time in Lismore, a NSW town 45 kilometres west of Byron, while they were infectious.

No details of a Queensland traveller were mentioned in the NSW briefing.