A woman has died in police custody after she was found unresponsive at a police station in Melbourne's east yesterday.

The 40-year-old woman from Ringwood was taken into custody at Knox police station on December 2 and was awaiting a remand hearing.

She was found unresponsive when police custody officers conducted routine checks just before 8pm.

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Officers called an ambulance and commenced CPR.

She was taken to hospital and later died.

Victoria Police in a statement said homicide squad detectives would investigate the death, with oversight from the Professional Standards Command as per standard protocol when a person dies in custody.