A man has died and three others are seriously injured after a car overturned in Victoria's north-east.

Police say the car had rolled at the intersection of Greta Road and Clarkes Lane, before coming to rest in a paddock, about 7.15pm in Wangaratta.

A 26-year-old passenger, from Beaconsfield, died at the scene.

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A 24-year-old Beaconsfield man suffered life-threatening injuries and was airlifted to hospital.

A 16-year-old Wangaratta boy was also airlifted to hospital with serious injuries.

The driver of the car, a 23-year-old Wangaratta man, was taken to a local hospital, where he remains with non-life-threatening injuries, and under police guard.

Major Collision Investigation Unit detectives are investigating the circumstances surrounding the crash.

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