A man with an axe in his bag has surrendered to police after an incident in the car park of the Crime and Corruption Commission headquarters building in Brisbane.

Police received a call about an armed 49-year-old man inside the CCC building on Saint Pauls Terrace in Fortitude Valley at around 4.20pm.

"At 5.45pm, the man was taken into custody by police who have subsequently located a small tomahawk in the man's bag," Queensland Police said in a statement.

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He is currently assisting police with inquiries.

It is unclear what his motive was.

No one was injured during the incident.