A luxury heist in the Brisbane CBD saw criminals use a Mercedes to ram raid a store, swiping designer items worth hundreds of thousands.

The highly planned robbery was over in minutes, with police now hunting the bandits.

Officers say just after 3 am, a white Mercedes SUV smashed through the Hermes shop on Edwards Street with the offenders then jumping out and stealing hundreds of thousands of dollars worth of bags, jewellery and hats.

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They abandoned the first vehicle – stolen just days before- and stuffed their loot into two waiting getaway cars before taking off.

CCTV cameras down the street caught the cars on their high-speed getaway, even running a red light in their rush to get away.

Police aren't far behind with authorities saying they were within metres of catching one of the thieves – but they're still on the run.

How many products were stolen is unknown but the estimated losses are high, with some bags costing over $40,000.

Police are appealing for shoppers to keep an eye out for Hermes items for sale online.

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